Hi again,
There is a recently published article in Bioinformatics advance access by Geiger group in Israel. They have included another parameter to facilitate the analysis for linkage and association analysis. This can be found in IDB inference. If you have not used IDB inference before then you can look it up here .
Plink is more often used software for such analysis that I am saying because we also used it when undertaking Human Population Genetic course in Copenhagen ;).
Here author pour effort in explaining the error sensitivity of markers for analysis. They have utilized a modified Lander-Green Hidden Markov Model and output IDB status and error status for each maker. It gonna be hard for myself as I have never heard of Lander-Green form of markov model :(.
Here is a glimpse of model corresponding to a nuclear family of two parents and two siblings genotyped over positions(loci) along their genomes.
There is too much of math following my interest is breaking down :(.
There is a recently published article in Bioinformatics advance access by Geiger group in Israel. They have included another parameter to facilitate the analysis for linkage and association analysis. This can be found in IDB inference. If you have not used IDB inference before then you can look it up here .
Plink is more often used software for such analysis that I am saying because we also used it when undertaking Human Population Genetic course in Copenhagen ;).
Here author pour effort in explaining the error sensitivity of markers for analysis. They have utilized a modified Lander-Green Hidden Markov Model and output IDB status and error status for each maker. It gonna be hard for myself as I have never heard of Lander-Green form of markov model :(.
Here is a glimpse of model corresponding to a nuclear family of two parents and two siblings genotyped over positions(loci) along their genomes.
There is too much of math following my interest is breaking down :(.
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